Determination of the LD50 of ethanolic extracts of 5 medicinal plants from the coast and mountains of Peru - 2023.

Abstract

Objective: Determine the result of the comparison of the Lethal Dose 50 (LD50) of ethanolic extracts of 5 plants from the coast and mountains of Peru. Material and Methods: Basic design study The study will be inductive, experimental, transversal and prospective. The study will be experimental, because there will be influence of the researcher on the variables under study, on the other hand it will be a cross-sectional study, since it indicates that the data collection will be carried out in a single period of time and prospective since the data will be collected after the approach of the study. Results: By carrying out the tests between the different concentrations of the extracts and when they were subjected to the nauplii, it has been determined that the medicinal species from the coast are more toxic than the medicinal species from the mountains, this is due more than anything to two important factors that consider; The first is that the natural habitat that is conducive to our plants under study is the Andean zone and the second factor would be the influence of the coastal environment and human activities that somehow alter the concentrations of the active ingredients. In this way, the difference in DL50 in these two groups of medicinal species is evident in the results. Conclusions: the habitat of the medicinal species influences the concentration of the active ingredients and therefore the LD50.