
INVESTIGACIÓN ORIGINAL / ORIGINAL RESEARCH Palomino-Huarcaya R. et al.
Visionarios en ciencia y tecnología 2024; 9:61-72. 71
Evaluación de la calidad sicoquímica y microbiológica de una
formulación gelicada elaborada con colágeno a base de escamas de pescado
V. Cosmeceuticals: An emerging concept. Indian
Journal of Pharmacology. 2005; 37(3): 155-159.
DOI:10.4103/0253-7613.16211
9. ChoiSY, KoEJ,LeeYH,etal.Effectsofcollagen
tripeptidesupplementonskinproperties:aprospective,
randomized,controlledstudy. J Cosmet LaserTher.
2014;16(3):132-7.doi:10.3109/14764172.2013.8541
19
10.Sibilla S, Godfrey M, Brewer S, Budh-Raja A,
GenoveseL.AnOverviewof theBenecialEffects
of Hydrolysed Collagen as a Nutraceutical on Skin
Properties: Scientic Background and Clinical
Studies. The Open Nutraceuticals Journal. 2015;
8(1):29–42.Doi:10.2174/1876396001508010029
11.ZagueV,deFreitasV,daCostaRosaM,deCastro
GA, Jaeger RG, Machado-Santelli GM. Collagen
Hydrolysate Intake Increases Skin Collagen
ExpressionandSuppressesMatrixMetalloproteinase
2Activity.Journal of Medicinal Food.2011; 14(6):
618–624.https://doi.org/10.1089/jmf.2010.0085
12.Makgobole MU, Onwubu SC, Baruwa A, et al.
OptimizationofCollagenExtractionfromFishScales
UsingTris-GlycineBuffer:ATaguchiMethodological
Approach. Mar Drugs. 2024;22(12):562. DOI:
10.3390/md22120562
13.Silva AVS, Costa GM, Cruz G. Thermal Behavior
and Physicochemical Properties of Fish Scales for
the Generation of Value-Added Products.
ResearchGate.2024.DOI:10.1007/978-981-99-8593-
7_18
14.Coman A, Marin M, Roșca A , Kaya M,
Constantinescu R, Titorencu I. Marine Resources
Gels as Main Ingredient for Wound Healing
Biomaterials: Obtaining and CharacterizationGels.
2024;10(11):729.doi:10.3390/gels10110729.
15.Quispe-López C, Ramírez V, Rojas M. Evaluación
sicoquímica del colágeno extraído de escamas de
pescado amazónico para suplementos alimentarios.
RevPeruBiotecnol.2024;10(1):22–30.
16.Gutiérrez-Paredes L, Herrera S, Chávez R.
Estabilidad microbiológica de formulaciones
gelicadas con colágeno marino de escamas de
pescado.RevPeruQuímFarm.2024;60(2):55–63.
17.Alcántara-Valverde M, Rodríguez P, Torres L.
Desarrollo y evaluación sensorial de una gelatina
funcional elaborada con colágeno de escamas
de pescado amazónico. Rev Peru InvestigAliment.
2024;12(1):40–48.
18.Shoulders MD, Raines RT. Collagen structure
and stability.Annu Rev Biochem. 2009;78:929–58.
doi:10.1146/annurev.biochem.77.032207.120833
19.Ricard-Blum S. The collagen family. Cold Spring
HarbPerspectBiol.2011;3(1):a004978.doi:10.1101/
cshperspect.a004978
20.Varani J, Warner RL, Gharaee-Kermani M, et al.
Vitamin A antagonizes decreased cell growth and
elevatedcollagen-degradingmatrixmetalloproteinases
and stimulates collagen accumulation in naturally
agedhumanskin.JInvestDermatol.2000;114(3):480–
6.doi:10.1046/j.1523-1747.2000.00902.x
21.EzureT,AmanoS.Inuence of age on viscoelastic
properties of the dermis in human facial skin. Skin
ResTechnol.2010;16(3):292–8.doi:10.1111/j.1600-
0846.2010.00439.x
22.CzajkaA,KaniaEM,GenoveseL,et al. Daily oral
supplementation with collagen peptides combined
withvitaminsandmineralsimprovesskinelasticity,
hydration, and reduces wrinkles. Nutr Res.
2018;57:97-108.doi:10.1016/j.nutres.2018.06.001
23.Gómez-Guillén MC, Giménez B, López-Caballero
ME, Montero MP. Functional and bioactive properties
of collagen and gelatin from alternative sources:
A review. Food Hydrocoll. 2011;25(8):1813–27.
doi:10.1016/j.foodhyd.2011.02.007
24.Matmaroh K, Benjakul S, ProdpranT, Encarnacion
AB, Kishimura H. Characteristics of acid soluble
collagen and pepsin soluble collagen from scale of
spotted golden goatsh (Parupeneus heptacanthus).
Food Chem. 2011;129(3):1179–86. https://doi.
org/10.1016/j.foodchem.2011.05.099
25.Song E, Kim SY, Chun T, Byun HJ, Lee YM.
Collagenscaffoldsderivedfromamarinesourceand
their biocompatibility. Biomaterials.
2006;27(15):2951–61. doi:10.1016/j.biomaterials.
2006.01.015
26.Kim HK, Kim MG, Leem KH. Oral administration
ofmarinecollagenpeptidesenhancesskinhydration
and elasticity in human subjects: A randomized,
double-blind, placebo-controlled clinical trial. Mar
Drugs.2018;16(12):429.doi:10.3390/md16120429
27.Organización de las Naciones unidas para la
Alimentación y la Agricultura. Microbiological
hazardsinshandshproducts.FAOFisheriesand
Aquaculture Technical Paper 444; 2020. (Citado el
15deJuliodel2024).Disponibleen:https://www.
fao.org/3/y9324e/y9324e.pdf
28.Tseng YC, Yu RF, Lee CF, Wang WH. Bacterial
diversityinshscalesandskinmucusoffreshwater
sh cultured in Taiwan. Microbiol Res. 2019;223-
225:13–23.
29.Oesser S, Adam M, Babel W, Seifert J. Oral
administration of 14C labeled gelatin hydrolysate
leadstoanaccumulationofradioactivityincartilage
of mice (C57/BL). J Nutr. 1999;129(10):1891–5.
doi:10.1093/jn/129.10.1891
30.Codex Alimentarius. General Principles of Food
Hygiene.WashingtonDC:FAO/WHO;2020.(Citado
el15deJuliodel2024).Disponibleen:https://www.
fao.org/fao-who-codexalimentarius
31.MinisteriodeSaluddelPerú.ReglamentoSanitario
deAlimentos. Lima: Ministerio de Salud del Perú;
2022.